CENPJ antibody (AA 510-590)

Catalog No. ABIN7227832

This Rabbit Polyclonal antibody specifically detects CENPJ in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for CENPJ antibody (AA 510-590) (ABIN7227832)

Target: CENPJ (Centromere Protein J (CENPJ))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CENPJ antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CENPJ Antibody

Binding Specificity: AA 510-590

Purpose: CENPJ Polyclonal Antibody

Specificity: The antibody detects endogenous levels of CENPJ protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human CENPJ protein at AA range: 510-590

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for CENPJ

Target: CENPJ (Centromere Protein J (CENPJ))

Alternative Name: CENPJ

Background: Rabbit Anti-CENPJ Polyclonal Antibody,Centromere protein J, CENP-J, Centrosomal P4.1-associated protein, LAG-3-associated protein, LYST-interacting protein 1,CENPJ (Centromere Protein J) encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in CENPJ are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for CENPJ.,CENPJ

Molecular Weight: observerd band 147kDa

Gene ID: 55835

UniProt: Q9HC77

Pathways: M Phase