CEP57 antibody (AA 210-290)

Catalog No. ABIN7226070

This anti-CEP57 antibody is a Rabbit Polyclonal antibody detecting CEP57 in WB and ELISA. Suitable for Human.

Quick Overview for CEP57 antibody (AA 210-290) (ABIN7226070)

Target: CEP57 (Centrosomal Protein 57kDa (CEP57))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP57 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CEP57 Antibody

Binding Specificity: AA 210-290

Purpose: CEP57 Polyclonal Antibody

Specificity: CEP57 Polyclonal Antibody detects endogenous levels of CEP57 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human CEP57 at AA range: 210-290

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for CEP57

Target: CEP57 (Centrosomal Protein 57kDa (CEP57))

Alternative Name: CEP57

Background: Rabbit Anti-CEP57 Polyclonal Antibody,CEP57, KIAA0092, TSP57, Centrosomal protein of 57 kDa, Cep57, FGF2-interacting protein, Testis-specific protein 57, Translokin,CEP57 (centrosomal protein 57) encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in CEP57 cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.,Centrosomal protein of 57 kDa

Molecular Weight: observerd band 50kDa

Gene ID: 9702

UniProt: Q86XR8

Pathways: M Phase, Maintenance of Protein Location, Protein targeting to Nucleus, Growth Factor Binding