CEP57 antibody

Catalog No. ABIN7252420

Product Details anti-CEP57 Antibody

Target: CEP57 (Centrosomal Protein 57kDa (CEP57))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP57 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Full length fusion protein

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CEP57

Target: CEP57 (Centrosomal Protein 57kDa (CEP57))

Alternative Name: CEP57 (CEP57 Products)

Synonyms: 3110002L15RIK antibody, CEP57 antibody, cep57r antibody, xCep57 antibody, c6orf182 antibody, 3110002l15rik antibody, RGD1309884 antibody, 3110002L15Rik antibody, 4921510P06Rik antibody, 4931428M20Rik antibody, AI467480 antibody, Tsp57 antibody, mKIAA0092 antibody, MVA2 antibody, PIG8 antibody, TSP57 antibody, centrosomal protein 57 antibody, centrosomal protein 57kDa-like 1 antibody, CEP57 antibody, cep57l1 antibody, Cep57 antibody

Background: This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 57 kDa

UniProt: Q86XR8

Pathways: M Phase, Maintenance of Protein Location, Protein targeting to Nucleus, Growth Factor Binding