CBLN2 antibody (AA 130-210)

Catalog No. ABIN7214156

This anti-CBLN2 antibody is a Rabbit Polyclonal antibody detecting CBLN2 in WB and ELISA. Suitable for Human, Rat, Mouse and Monkey.

Quick Overview for CBLN2 antibody (AA 130-210) (ABIN7214156)

Target: CBLN2 (Cerebellin 2 Precursor (CBLN2))

Reactivity: Human, Rat, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBLN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CBLN2 Antibody

Binding Specificity: AA 130-210

Purpose: Cerebellin 2 Polyclonal Antibody

Specificity: Cerebellin 2 Polyclonal Antibody detects endogenous levels of Cerebellin 2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human Cerebellin 2 at AA range: 130-210

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for CBLN2

Target: CBLN2 (Cerebellin 2 Precursor (CBLN2))

Alternative Name: Cerebellin 2

Background: Rabbit Anti-Cerebellin 2 Polyclonal Antibody,CBLN2, Cerebellin-2,Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. CER and it metabolite des-Ser1-cerebellin are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other's degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of CER has been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for CER in the pathology of these diseases.,Cerebellin-2

Molecular Weight: observerd band 24kDa

Gene ID: 147381

UniProt: Q8IUK8