C9orf89 antibody (AA 40-120)

Catalog No. ABIN7225394

This Rabbit Polyclonal antibody specifically detects C9orf89 in ELISA, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for C9orf89 antibody (AA 40-120) (ABIN7225394)

Target: C9orf89 (Chromosome 9 Open Reading Frame 89 (C9orf89))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C9orf89 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-C9orf89 Antibody

Binding Specificity: AA 40-120

Purpose: Rabbit Anti-BinCARD Polyclonal Antibody

Specificity: BinCARD Polyclonal Antibody detects endogenous levels of BinCARD protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human BinCARD at AA range: 40-120

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for C9orf89

Target: C9orf89 (Chromosome 9 Open Reading Frame 89 (C9orf89))

Alternative Name: BinCARD

Background: C9orf89, Bcl10-interacting CARD protein, BinCARDBinCARD (Bcl10-interacting CARD protein) is a 228 amino acid protein that exists as two alternatively spiced isoforms. BinCARD localizes to nucleus and is expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart, liver, thymus and brain. Containing a CARD domain, BinCARD plays a role in inhibiting the effects of Bcl10-induced activation of NFκB possibly by inhibiting the phosphorylation of Bcl10 in a CARD-dependent manner. The BinCARD gene maps to chromosome 9q22.1. Chromosome 9 consists of about 145 million bases and 4 % of the human genome and encodes nearly 900 genes. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKAP.

Gene ID: 84270

UniProt: Q96LW7