Claudin 11 antibody (AA 130-210)

Catalog No. ABIN7222878

This anti-Claudin 11 antibody is a Rabbit Polyclonal antibody detecting Claudin 11 in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for Claudin 11 antibody (AA 130-210) (ABIN7222878)

Target: Claudin 11 (CLDN11)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 11 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Claudin 11 Antibody

Binding Specificity: AA 130-210

Purpose: Claudin-11 Polyclonal Antibody

Specificity: Claudin-11 Polyclonal Antibody detects endogenous levels of Claudin-11 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human Claudin-11 at AA range: 130-210

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Claudin 11

Target: Claudin 11 (CLDN11)

Alternative Name: Claudin-11

Background: Rabbit Anti-Claudin-11 Polyclonal Antibody,CLDN11, OSP, OTM, Claudin-11, Oligodendrocyte-specific protein,CLDN11 encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by CLDN11 is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein claudin 11 is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.,Claudin-11

Molecular Weight: observerd band 20kDa

Gene ID: 5010

UniProt: O75508

Pathways: Hepatitis C