Cyclin T1 antibody (AA 220-300)

Catalog No. ABIN7227666

This Rabbit Polyclonal antibody specifically detects Cyclin T1 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for Cyclin T1 antibody (AA 220-300) (ABIN7227666)

Target: Cyclin T1 (CCNT1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin T1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Cyclin T1 Antibody

Binding Specificity: AA 220-300

Purpose: CCNT1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of CCNT1 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human CCNT1 protein at AA range: 220-300

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Cyclin T1

Target: Cyclin T1 (CCNT1)

Alternative Name: CCNT1

Background: Rabbit Anti-CCNT1 Polyclonal Antibody,Cyclin-T1, CycT1, Cyclin-T,CCNT1 (Cyclin T1) encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of CCNT1 is implicated in tumor growth. Alternative splicing results in multiple transcript variants.,CCNT1

Molecular Weight: observerd band 79kDa

Gene ID: 904

UniProt: O60563