CYB561D1 antibody (AA 160-240)

Catalog No. ABIN7221226

This Rabbit Polyclonal antibody specifically detects CYB561D1 in WB, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for CYB561D1 antibody (AA 160-240) (ABIN7221226)

Target: CYB561D1 (Cytochrome B-561 Domain Containing 1 (CYB561D1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYB561D1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-CYB561D1 Antibody

Binding Specificity: AA 160-240

Purpose: CYB561D1 Polyclonal Antibody

Specificity: CYB561D1 Polyclonal Antibody detects endogenous levels of CYB561D1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human CYB561D1 at AA range: 160-240

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IF (1:200-1:1000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for CYB561D1

Target: CYB561D1 (Cytochrome B-561 Domain Containing 1 (CYB561D1))

Alternative Name: CYB561D1

Background: Rabbit Anti-CYB561D1 Polyclonal Antibody,CYB561D1, Cytochrome b561 domain-containing protein 1,CYB561D2 (Cytochrome b561 domain-containing protein 2), also known as putative tumor suppressor protein 101F6, is a 222 amino acid highly hydrophobic protein that contains six membrane spanning domains. Localized to endosomes and endoplasmic reticulum of the perinuclear region, CYB561D2 contains 2 heme-binding sites, through which it reduces ferric ions. CYB561D2 is ubiquitously expressed, with highest levels in lung, liver and kidney. Though expression of CYB561D2 is abundant in normal lung bronchial epithileal cells, CYB561D2 is absent in most lung cancers. The gene encoding CYB561D2 maps to human chromosome 3p21.3, a region that is prone to genetic alterations and is associated with frequent and early allele loss in many human cancers. Exogenous expression of CYB561D2 leads to the induction of caspase-independent apoptotic and autophagic pathways, resulting in the synergistic killing of tumor cells. This suggests an important role for CYB561D2 as a therapeutic intervention in cancer treatment.,Cytochrome b561 domain-containing protein 1

Molecular Weight: observerd band 23kDa

Gene ID: 284613

UniProt: Q8N8Q1