Desmoglein 1 antibody (AA 30-90)

Catalog No. ABIN7228306

This anti-Desmoglein 1 antibody is a Rabbit Polyclonal antibody detecting Desmoglein 1 in WB, ELISA and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for Desmoglein 1 antibody (AA 30-90) (ABIN7228306)

Target: Desmoglein 1 (DSG1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmoglein 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Desmoglein 1 Antibody

Binding Specificity: AA 30-90

Purpose: Dsg1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of Dsg1

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human Dsg1 protein at AA range: 30-90

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:500-1:200), ELISA (1:10000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Desmoglein 1

Target: Desmoglein 1 (DSG1)

Alternative Name: Dsg1

Background: Rabbit Anti-Dsg1 Polyclonal Antibody,Desmoglein-1, Cadherin family member 4, Desmosomal glycoprotein 1, DG1, DGI, Pemphigus foliaceus antigen,DSG1 encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. DSG1 is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of DSG1 has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.,Dsg1

Molecular Weight: observerd band 160kDa

Gene ID: 1828

UniProt: Q02413

Pathways: Cell-Cell Junction Organization