Desmoglein 2 antibody (AA 370-450)

Catalog No. ABIN7220094

This Rabbit Polyclonal antibody specifically detects Desmoglein 2 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for Desmoglein 2 antibody (AA 370-450) (ABIN7220094)

Target: Desmoglein 2 (DSG2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmoglein 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Desmoglein 2 Antibody

Binding Specificity: AA 370-450

Purpose: Dsg2 Polyclonal Antibody

Specificity: Dsg2 Polyclonal Antibody detects endogenous levels of Dsg2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Dsg2 at AA range: 370-450

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Desmoglein 2

Target: Desmoglein 2 (DSG2)

Alternative Name: Dsg2

Background: Rabbit Anti-Dsg2 Polyclonal Antibody,DSG2, CDHF5, Desmoglein-2, Cadherin family member 5, HDGC,DSG2 encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. DSG2 is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.,Desmoglein-2

Molecular Weight: observerd band 140kDa

Gene ID: 1829

UniProt: Q14126

Pathways: Cell-Cell Junction Organization