DOK6 antibody (AA 80-160)

Catalog No. ABIN7214610

The Rabbit Polyclonal anti-DOK6 antibody is suitable to detect DOK6 in samples from Human and Mouse. It has been validated for WB, ELISA, IF and IHC (p).

Quick Overview for DOK6 antibody (AA 80-160) (ABIN7214610)

Target: DOK6 (Docking Protein 6 (DOK6))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOK6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DOK6 Antibody

Binding Specificity: AA 80-160

Purpose: Dok-6 Polyclonal Antibody

Specificity: Dok-6 Polyclonal Antibody detects endogenous levels of Dok-6 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Dok-6 at AA range: 80-160

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for DOK6

Target: DOK6 (Docking Protein 6 (DOK6))

Alternative Name: Dok-6

Background: Rabbit Anti-Dok-6 Polyclonal Antibody,DOK6, DOK5L, Docking protein 6, Downstream of tyrosine kinase 6,The downstream of kinase family (Dok-1-7) are members of a class of "docking" proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.,Docking protein 6

Molecular Weight: observerd band 43kDa

Gene ID: 220164

UniProt: Q6PKX4