DOK7 antibody (AA 10-90)

Catalog No. ABIN7221244

This anti-DOK7 antibody is a Rabbit Polyclonal antibody detecting DOK7 in WB, ELISA, IF and IHC (p). Suitable for Human and Mouse.

Quick Overview for DOK7 antibody (AA 10-90) (ABIN7221244)

Target: DOK7 (Docking Protein 7 (DOK7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOK7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DOK7 Antibody

Binding Specificity: AA 10-90

Purpose: Dok-7 Polyclonal Antibody

Specificity: Dok-7 Polyclonal Antibody detects endogenous levels of Dok-7 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the N-terminal region of human Dok-7 at AA range: 10-90

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for DOK7

Target: DOK7 (Docking Protein 7 (DOK7))

Alternative Name: Dok-7

Background: Rabbit Anti-Dok-7 Polyclonal Antibody,DOK7, C4orf25, Protein Dok-7, Downstream of tyrosine kinase 7,The docking protein 7 encoded by DOK7 is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in DOK7 are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.,Protein Dok-7

Molecular Weight: observerd band 60kDa

Gene ID: 285489

UniProt: Q18PE1

Pathways: Skeletal Muscle Fiber Development