DR4 antibody (AA 370-450)

Catalog No. ABIN7214618

This anti-DR4 antibody is a Rabbit Polyclonal antibody detecting DR4 in WB, ELISA and IF. Suitable for Human and Monkey.

Quick Overview for DR4 antibody (AA 370-450) (ABIN7214618)

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DR4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-DR4 Antibody

Binding Specificity: AA 370-450

Purpose: DR4 Polyclonal Antibody

Specificity: DR4 Polyclonal Antibody detects endogenous levels of DR4 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human DR4 at AA range: 370-450

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for DR4

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Alternative Name: DR4

Background: Rabbit Anti-DR4 Polyclonal Antibody,TNFRSF10A, APO2, DR4, TRAILR1, Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1, CD antigen CD261,TNF receptor superfamily member 10a encoded by TNFRSF10A is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.,Tumor necrosis factor receptor superfamily member 10A

Molecular Weight: observerd band 50kDa

Gene ID: 8797

UniProt: O00220

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity