Dysferlin antibody (AA 1950-2030)

Catalog No. ABIN7225232

This anti-Dysferlin antibody is a Rabbit Polyclonal antibody detecting Dysferlin in WB, ELISA and IF. Suitable for Human and Mouse.

Quick Overview for Dysferlin antibody (AA 1950-2030) (ABIN7225232)

Target: Dysferlin (DYSF)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dysferlin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-Dysferlin Antibody

Binding Specificity: AA 1950-2030

Purpose: Dysferlin Polyclonal Antibody

Specificity: Dysferlin Polyclonal Antibody detects endogenous levels of Dysferlin protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human Dysferlin at AA range: 1950-2030

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Dysferlin

Target: Dysferlin (DYSF)

Alternative Name: Dysferlin

Background: Rabbit Anti-Dysferlin Polyclonal Antibody,DYSF, FER1L1, Dysferlin, Dystrophy-associated fer-1-like protein, Fer-1-like protein 1,The protein encoded by DYSF (dysferlin) belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by DYSF binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in DYSF have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants.,Dysferlin

Molecular Weight: observerd band 240kDa

Gene ID: 8291

UniProt: O75923