ELAC2 antibody (AA 130-210)

Catalog No. ABIN7224036

This Rabbit Polyclonal antibody specifically detects ELAC2 in ELISA and IHC (p). It exhibits reactivity toward Human.

Quick Overview for ELAC2 antibody (AA 130-210) (ABIN7224036)

Target: ELAC2 (ElaC Homolog 2 (ELAC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELAC2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ELAC2 Antibody

Binding Specificity: AA 130-210

Purpose: RNase Z2 Polyclonal Antibody

Specificity: RNase Z2 Polyclonal Antibody detects endogenous levels of RNase Z2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human RNase Z2 at AA range: 130-210

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for ELAC2

Target: ELAC2 (ElaC Homolog 2 (ELAC2))

Alternative Name: RNase Z2

Background: Rabbit Anti-RNase Z2 Polyclonal Antibody,ELAC2, HPC2, Zinc phosphodiesterase ELAC protein 2, ElaC homolog protein 2, Heredity prostate cancer protein 2, Ribonuclease Z 2, RNase Z 2, tRNA 3 endonuclease 2, tRNase Z 2,The protein encoded by ELAC2 (elaC ribonuclease Z 2) has a C-terminal domain with tRNA processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in ELAC2 result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for ELAC2.,Zinc phosphodiesterase ELAC protein 2

Gene ID: 60528

UniProt: Q9BQ52