ELL3 antibody (AA 210-290)

Catalog No. ABIN7228382

This Rabbit Polyclonal antibody specifically detects ELL3 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for ELL3 antibody (AA 210-290) (ABIN7228382)

Target: ELL3 (Elongation Factor RNA Polymerase II-Like 3 (ELL3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELL3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ELL3 Antibody

Binding Specificity: AA 210-290

Purpose: ELL3 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of ELL3 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human ELL3 protein at AA range: 210-290

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for ELL3

Target: ELL3 (Elongation Factor RNA Polymerase II-Like 3 (ELL3))

Alternative Name: ELL3

Background: Rabbit Anti-ELL3 Polyclonal Antibody,RNA polymerase II elongation factor ELL3,ELL3 (Elongation Factor For RNA Polymerase II 3) is a Protein Coding gene. Among its related pathways are RNA polymerase II transcribes snRNA genes and Gene Expression. Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.,ELL3

Molecular Weight: observerd band 43kDa

Gene ID: 80237

UniProt: Q9HB65

Pathways: Negative Regulation of intrinsic apoptotic Signaling