XPO1 antibody (acLys568)

Catalog No. ABIN7212648

The Rabbit Polyclonal anti-XPO1 antibody has been validated for WB and ELISA. It is suitable to detect XPO1 in samples from Human, Mouse and Rat.

Quick Overview for XPO1 antibody (acLys568) (ABIN7212648)

Target: XPO1 (Exportin 1 (XPO1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPO1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-XPO1 Antibody

Binding Specificity: acLys568

Purpose: CRM1 (Acetyl Lys568) Polyclonal Antibody

Specificity: Acetyl-CRM1 (K568) Polyclonal Antibody detects endogenous levels of CRM1 protein only when non-acetylation at K568.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human CRM1 around the acetylation site of K568

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for XPO1

Target: XPO1 (Exportin 1 (XPO1))

Alternative Name: CRM1

Background: Rabbit Anti-CRM1 (Acetyl Lys568) Polyclonal Antibody,XPO1, CRM1, Exportin-1, Exp1, Chromosome region maintenance 1 protein homolog,This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. Exportin 1 also regulates NFAT and AP-1.,Exportin-1

Molecular Weight: observerd band 125kDa

Gene ID: 7514

UniProt: O14980

Pathways: M Phase