Exportin 7 antibody

Catalog No. ABIN7232184

This anti-Exportin 7 antibody is a Rabbit Polyclonal antibody detecting Exportin 7 in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for Exportin 7 antibody (ABIN7232184)

Target: Exportin 7 (XPO7)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exportin 7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Exportin 7 Antibody

Purpose: XPO7 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of XPO7 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human XPO7 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Exportin 7

Target: Exportin 7 (XPO7)

Alternative Name: XPO7

Background: Rabbit Anti-XPO7 Polyclonal Antibody,Exportin-7, Exp7, Ran-binding protein 16,Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.,XPO7

Molecular Weight: observerd band 119kDa

Gene ID: 23039

UniProt: Q9UIA9