Filamin A antibody (pSer2152)

Catalog No. ABIN7213236

This anti-Filamin A antibody is a Rabbit Polyclonal antibody detecting Filamin A in WB, ELISA and IHC (p). Suitable for Human, Mouse, Rat and Monkey.

Quick Overview for Filamin A antibody (pSer2152) (ABIN7213236)

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Filamin A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Filamin A Antibody

Binding Specificity: pSer2152

Purpose: Filamin 1 (phospho Ser2152) Polyclonal Antibody

Specificity: Phospho-Filamin 1 (S2152) Polyclonal Antibody detects endogenous levels of Filamin 1 protein only when phosphorylated at S2152.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human Filamin 1 Phospho-Ser2152

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Filamin A

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Alternative Name: Filamin 1

Background: Rabbit Anti-Filamin 1 (phospho Ser2152) Polyclonal Antibody,FLNA, FLN, FLN1, Filamin-A, FLN-A, Actin-binding protein 280, ABP-280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1, Non-muscle filamin,Filamin A encoded by FLNA is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. Filamin A is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in FLNA are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for FLNA.,Filamin-A

Molecular Weight: observerd band 280kDa

Gene ID: 2316

UniProt: P21333

Pathways: TCR Signaling, Maintenance of Protein Location