Gelsolin antibody

Catalog No. ABIN7228646

The Rabbit Polyclonal anti-Gelsolin antibody is suitable to detect Gelsolin in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for Gelsolin antibody (ABIN7228646)

Target: Gelsolin (GSN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gelsolin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Gelsolin Antibody

Purpose: GELS Polyclonal Antibody

Specificity: The antibody detects endogenous levels of GELS protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human GELS protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Gelsolin

Target: Gelsolin (GSN)

Alternative Name: GELS

Background: Rabbit Anti-GELS Polyclonal Antibody,Gelsolin, AGEL, Actin-depolymerizing factor, ADF, Brevin,Gelsolin encoded by GSN binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for GSN. GSN (Gelsolin) is a Protein Coding gene. Diseases associated with GSN include Amyloidosis, Finnish Type and Lattice Corneal Dystrophy Type Ii. Among its related pathways are Apoptosis and survival Caspase cascade and N-cadherin signaling events.,GELS

Molecular Weight: observerd band 86kDa

Gene ID: 2934

UniProt: P06396

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy