GRIA4 antibody

Catalog No. ABIN7221302

The Rabbit Polyclonal anti-GRIA4 antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect GRIA4 in samples from Human, Mouse and Rat.

Quick Overview for GRIA4 antibody (ABIN7221302)

Target: GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIA4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GRIA4 Antibody

Purpose: GluR4 Polyclonal Antibody

Specificity: GluR4 Polyclonal Antibody detects endogenous levels of GluR4 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human GluR4 around the non-phosphorylation site of S862

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for GRIA4

Target: GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))

Alternative Name: GluR4

Background: Rabbit Anti-GluR4 Polyclonal Antibody,GRIA4, GLUR4, Glutamate receptor 4, GluR-4, GluR4, AMPA-selective glutamate receptor 4, GluR-D, Glutamate receptor ionotropic, AMPA 4, GluA4,Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by GRIA4 belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA, R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of GRIA4 show a positive association with schizophrenia.,Glutamate receptor 4

Molecular Weight: observerd band 100kDa

Gene ID: 2893

UniProt: P48058

Pathways: PI3K-Akt Signaling