GREM2 antibody (AA 71-120)

Catalog No. ABIN7228780

The Rabbit Polyclonal anti-GREM2 antibody is suitable to detect GREM2 in samples from Human and Mouse. It has been validated for WB, ELISA and IHC (p).

Quick Overview for GREM2 antibody (AA 71-120) (ABIN7228780)

Target: GREM2 (Gremlin 2 (GREM2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GREM2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GREM2 Antibody

Binding Specificity: AA 71-120

Purpose: Gremlin-2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of Gremlin-2

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human Gremlin-2 protein at AA range: 71-120

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:500-1:200), ELISA (1:10000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for GREM2

Target: GREM2 (Gremlin 2 (GREM2))

Alternative Name: Gremlin-2

Background: Rabbit Anti-Gremlin-2 Polyclonal Antibody,Gremlin-2, Cysteine knot superfamily 1, BMP antagonist 2, DAN domain family member 3, Protein related to DAN and cerberus,Gremlin-2 encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which Gremlin-2 belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, Gremlin-2 may play a role in regulating organogenesis, body patterning, and tissue differentiation.,Gremlin-2

Molecular Weight: observerd band 19kDa

Gene ID: 64388

UniProt: Q9H772