HSPB8 antibody

Catalog No. ABIN7212116

This Mouse Monoclonal antibody specifically detects HSPB8 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for HSPB8 antibody (ABIN7212116)

Target: HSPB8 (Heat Shock 22kDa Protein 8 (HSPB8))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This HSPB8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HSPB8 Antibody

Purpose: HSPB8/HSP22 Monoclonal Antibody

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen

Immunogen: Recombinant Protein

Isotype: IgG1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:1000-1:2000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for HSPB8

Target: HSPB8 (Heat Shock 22kDa Protein 8 (HSPB8))

Alternative Name: HSPB8/HSP22

Background: Mouse Anti-HSPB8/HSP22 Monoclonal Antibody,HSPB8, CRYAC, E2IG1, HSP22, PP1629, Heat shock protein beta-8, HspB8, Alpha-crystallin C chain, E2-induced gene 1 protein, Protein kinase H11, Small stress protein-like protein HSP22,The protein encoded by HSPB8 (heat shock protein family B (small) member 8) belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of HSPB8 in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, HSPB8 appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in HSPB8 have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.,HSPB8

Molecular Weight: observerd band 22kDa

Gene ID: 26353

UniProt: Q9UJY1