ITFG2 antibody (AA 40-120)

Catalog No. ABIN7229200

The Rabbit Polyclonal anti-ITFG2 antibody has been validated for WB and ELISA. It is suitable to detect ITFG2 in samples from Human and Mouse.

Quick Overview for ITFG2 antibody (AA 40-120) (ABIN7229200)

Target: ITFG2 (Integrin alpha FG-GAP Repeat Containing 2 (ITFG2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITFG2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ITFG2 Antibody

Binding Specificity: AA 40-120

Purpose: ITFG2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of ITFG2 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human ITFG2 protein at AA range: 40-120

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for ITFG2

Target: ITFG2 (Integrin alpha FG-GAP Repeat Containing 2 (ITFG2))

Alternative Name: ITFG2

Background: Rabbit Anti-ITFG2 Polyclonal Antibody,KICSTOR complex protein ITFG2, Integrin-alpha FG-GAP repeat-containing protein 2,ITFG2 (Integrin Alpha FG-GAP Repeat Containing 2) is a Protein Coding gene. Diseases associated with ITFG2 include Distal Arthrogryposis. As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.,ITFG2

Molecular Weight: observerd band 49kDa

Gene ID: 55846

UniProt: Q969R8