Integrin Alpha6 LC (AA 900-980), (Cleaved-Glu942) antibody

Catalog No. ABIN7212522

This Rabbit Polyclonal antibody specifically detects Integrin Alpha6 LC in ELISA and WB. It exhibits reactivity toward Human.

Quick Overview for Integrin Alpha6 LC (AA 900-980), (Cleaved-Glu942) antibody (ABIN7212522)

Target: Integrin Alpha6 LC

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details

Binding Specificity: AA 900-980, Cleaved-Glu942

Purpose: Cleaved-Integrin α6 LC (E942) Polyclonal Antibody

Specificity: Cleaved-Integrin α6 LC (E942) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin α6 LC protein resulting from cleavage adjacent to E942.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human Integrin alpha6 LC at AA range: 900-980

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details

Target: Integrin Alpha6 LC

Background: Rabbit Anti-Cleaved-Integrin α6 LC (E942) Polyclonal Antibody,ITGA6, Integrin alpha-6, CD49 antigen-like family member F, VLA-6, CD antigen CD49f,ITGA6 encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.,Integrin alpha-6

Molecular Weight: observerd band 28kDa

Gene ID: 3655

UniProt: P23229