ITGB3BP antibody (AA 10-90)

Catalog No. ABIN7227848

This Rabbit Polyclonal antibody specifically detects ITGB3BP in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for ITGB3BP antibody (AA 10-90) (ABIN7227848)

Target: ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGB3BP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ITGB3BP Antibody

Binding Specificity: AA 10-90

Purpose: CENPR Polyclonal Antibody

Specificity: The antibody detects endogenous levels of CENPR protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human CENPR protein at AA range: 10-90

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for ITGB3BP

Target: ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Alternative Name: CENPR

Background: Rabbit Anti-CENPR Polyclonal Antibody,Centromere protein R, CENP-R, Beta-3-endonexin, Integrin beta-3-binding protein, Nuclear receptor-interacting factor 3,ITGB3BP (Integrin Subunit Beta 3 Binding Protein) encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. ITGB3BP also acts as a corepressor of NF-kappaB-dependent signaling. ITGB3BP induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. ITGB3BP is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.,CENPR

Molecular Weight: observerd band 19kDa

Gene ID: 23421

UniProt: Q13352

Pathways: Neurotrophin Signaling Pathway