JAK2/3 antibody (pTyr939, pTyr966)

Catalog No. ABIN7229208

This anti-JAK2/3 antibody is a Rabbit Polyclonal antibody detecting JAK2/3 in WB and ICC. Suitable for Human, Mouse and Rat.

Quick Overview for JAK2/3 antibody (pTyr939, pTyr966) (ABIN7229208)

Target: JAK2/3 (Janus Kinase 2/3 (JAK2/3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAK2/3 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Product Details anti-JAK2/3 Antibody

Binding Specificity: pTyr939, pTyr966

Purpose: JAK2/3 (Phospho-Tyr966/939) Polyclonal Antibody

Specificity: The antibody detects endogenous levels of JAK2/3 when Phospho occurs at Tyr966/939(human) or Tyr966/935(mouse/rat) , It doesn't react with total protein.

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human JAK2/3 (Phospho-Tyr966/939) Antibody protein at AA range: T966

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:1000), ICC (1:200). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for JAK2/3

Target: JAK2/3 (Janus Kinase 2/3 (JAK2/3))

Alternative Name: JAK2/3

Background: Rabbit Anti-JAK2/3 (Phospho-Tyr966/939) Polyclonal Antibody,Tyrosine-protein kinase JAK2/JAK3, Janus kinase 2/Janus kinase 3, JAK-2/JAK-3,JAK2 is a kinase that is misregulated or mutated in a number of myeloproliferative diseases and cancers. The mutation V617F is the most clinically relevant variant, and is seen in around half of myeloproliferative disorders. The variant is a known activating mutation, and activated JAK2 is sufficient to drive myeloproliferative disorders in mouse models. V617F, while most recurrent, is not the only mechanism by which JAK2 can be activated in patients. JAK2 is now one of the first diagnostic markers tested upon diagnosis with a myeloproliferative disorder.,JAK2/3

Gene ID: 1132, 1124