pan Keratin antibody (AA 150-220)

Catalog No. ABIN7229282

This Rabbit Polyclonal antibody specifically detects pan Keratin in IHC, WB and ELISA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for pan Keratin antibody (AA 150-220) (ABIN7229282)

Target: pan Keratin (panKRT)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This pan Keratin antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Product Details anti-pan Keratin Antibody

Binding Specificity: AA 150-220

Purpose: Rabbit Anti-Keratin-pan Polyclonal Antibody

Specificity: The antibody detects endogenous levels of Keratin-pan

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human Keratin-pan protein at AA range: 150-220

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for pan Keratin

Target: pan Keratin (panKRT)

Alternative Name: Keratin-pan

Background: Keratin, type II cytoskeletal 2 epidermal, KRT2, Cytokeratin-2e, CK-2e, Epithelial keratin-2e, Keratin-2 epidermis, Keratin-2e, K2e, Type-II keratin Kb2, KRT2, KRT2A, KRT2EThe protein encoded by KRT2 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in KRT2 have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. KRT2 (Keratin 2) is a Protein Coding gene. Diseases associated with KRT2 include Ichthyosis Bullosa Of Siemens and Exfoliative Ichthyosis. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Keratinization.

Molecular Weight: 70kD

Gene ID: 3849

UniProt: P35908, Q01546, P12035, P13647, P02538, P04259, P48668, Q3SY84, Q14CN4, Q86Y46, Q7RTS7, O95678, Q5XKE5, P08729, P05787, Q9NSB2