Latrophilin 1 antibody (AA 530-610)

Catalog No. ABIN7220562

The Rabbit Polyclonal anti-Latrophilin 1 antibody has been validated for ELISA and IF. It is suitable to detect Latrophilin 1 in samples from Rat, Human and Mouse.

Quick Overview for Latrophilin 1 antibody (AA 530-610) (ABIN7220562)

Target: Latrophilin 1 (LPHN1)

Reactivity: Rat, Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Latrophilin 1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-Latrophilin 1 Antibody

Binding Specificity: AA 530-610

Purpose: Latrophilin-1 Polyclonal Antibody

Specificity: Latrophilin-1 Polyclonal Antibody detects endogenous levels of Latrophilin-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Latrophilin-1 at AA range: 530-610

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Latrophilin 1

Target: Latrophilin 1 (LPHN1)

Alternative Name: Latrophilin-1

Background: Rabbit Anti-Latrophilin-1 Polyclonal Antibody,LPHN1, KIAA0821, LEC2, Latrophilin-1, Calcium-independent alpha-latrotoxin receptor 1, CIRL-1, Lectomedin-2,ADGRL1 encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.,Latrophilin-1

Gene ID: 22859

UniProt: O94910

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis