LRP3 antibody (AA 30-110)

Catalog No. ABIN7222266

The Rabbit Polyclonal anti-LRP3 antibody (ABIN7222266) specifically detects LRP3 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for LRP3 antibody (AA 30-110) (ABIN7222266)

Target: LRP3 (Low Density Lipoprotein Receptor-Related Protein 3 (LRP3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-LRP3 Antibody

Binding Specificity: AA 30-110

Purpose: LRP3 Polyclonal Antibody

Specificity: LRP3 Polyclonal Antibody detects endogenous levels of LRP3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the N-terminal region of human LRP3 at AA range: 30-110

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for LRP3

Target: LRP3 (Low Density Lipoprotein Receptor-Related Protein 3 (LRP3))

Alternative Name: LRP3

Background: Rabbit Anti-LRP3 Polyclonal Antibody,LRP3, Low-density lipoprotein receptor-related protein 3, LRP-3, 105 kDa low-density lipoprotein receptor-related protein, hLRp105,NLRP3, also known as NALP3, CIAS1, PYPAF or Cryopyrin, is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NLRP3 activates caspases 1 and 5. Defects in NLRP3 may cause FCAS1, CINCA, or Muckle-Wells autoinflammatory syndromes. Mouse NLRP3 contains an N-terminal Pyrin domain (aa 1-91) followed by a Nacht region (aa 216-532), and seven LRRs (aa 739-988). Within the sequence used as an immunogen, mouse NLRP3 shares 78 % and 93 % aa identity with human and rat NLRP3, respectively. Alternate splicing of mouse NLRP3 generates additional isoforms that lack either LRR2 and 3, LRR 6 and 7, or LRR4-9.,Low-density lipoprotein receptor-related protein 3

Molecular Weight: observerd band 80kDa

Gene ID: 4037

UniProt: O75074