MAP4K2 antibody (AA 400-480)

Catalog No. ABIN7229498

The Rabbit Polyclonal anti-MAP4K2 antibody has been validated for WB and ELISA. It is suitable to detect MAP4K2 in samples from Human.

Quick Overview for MAP4K2 antibody (AA 400-480) (ABIN7229498)

Target: MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP4K2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MAP4K2 Antibody

Binding Specificity: AA 400-480

Purpose: M4K2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of M4K2 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human M4K2 protein at AA range: 400-480

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for MAP4K2

Target: MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))

Alternative Name: M4K2

Background: Rabbit Anti-M4K2 Polyclonal Antibody,Mitogen-activated protein kinase kinase kinase kinase 2, B lymphocyte serine/threonine-protein kinase, Germinal center kinase, GC kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, MEKKK 2, Rab8-interacting protein,The protein encoded by MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2) is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. MAP4K2 is a Protein Coding gene. Diseases associated with MAP4K2 include Cerebral Cavernous Malformations-2. Among its related pathways are TGF-Beta Pathway and MAPK signaling pathway.,M4K2

Molecular Weight: observerd band 90kDa

Gene ID: 5871

UniProt: Q12851