MAX antibody (pSer2)

Catalog No. ABIN7222374

The Rabbit Polyclonal anti-MAX antibody has been validated for ELISA and IHC (p). It is suitable to detect MAX in samples from Human, Mouse and Rat.

Quick Overview for MAX antibody (pSer2) (ABIN7222374)

Target: MAX (MYC Associated Factor X (MAX))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAX antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-MAX Antibody

Binding Specificity: pSer2

Purpose: Max (phospho Ser2) Polyclonal Antibody

Specificity: Phospho-Max (S2) Polyclonal Antibody detects endogenous levels of Max protein only when phosphorylated at S2.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human Max Phospho-Ser2

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for MAX

Target: MAX (MYC Associated Factor X (MAX))

Alternative Name: Max

Background: Rabbit Anti-Max (phospho Ser2) Polyclonal Antibody,MAX, BHLHD4, Protein max, Class D basic helix-loop-helix protein 4, bHLHd4, Myc-associated factor X,The protein encoded by MAX is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants.,Protein max

Gene ID: 4149

UniProt: P61244

Pathways: Mitotic G1-G1/S Phases