NMDA epsilon 1/2 (pTyr1246), (pTyr1252) antibody

Catalog No. ABIN7221330

This Rabbit Polyclonal antibody specifically detects NMDA epsilon 1/2 in ELISA, IF and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NMDA epsilon 1/2 (pTyr1246), (pTyr1252) antibody (ABIN7221330)

Target: NMDA epsilon 1/2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: pTyr1246, pTyr1252

Purpose: NMDAε1/2 (phospho Tyr1246/1252) Polyclonal Antibody

Specificity: Phospho-NMDAε1/2 (Y1246/1252) Polyclonal Antibody detects endogenous levels of NMDAε1/2 protein only when phosphorylated at Y1246/1252.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human NMDAepsilon1/2 Phospho-Tyr1246/1252

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details

Target: NMDA epsilon 1/2

Alternative Name: NMDAepsilon1/2

Background: Rabbit Anti-NMDAε1/2 (phospho Tyr1246/1252) Polyclonal Antibody,GRIN2A, NMDAR2A, Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDAR2A, NR2A, hNR2A, GRIN2B, NMDAR2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, N,GRIN2A encodes a member of the glutamate-gated ion channel protein family. The glutamate ionotropic receptor NMDA type subunit 2A is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.,Glutamate [NMDA] receptor subunit epsilon-1

Gene ID: 2903, 2904