Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) (AA 170-250) antibody

Catalog No. ABIN7230470

This anti- antibody is a Rabbit Polyclonal antibody detecting in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) (AA 170-250) antibody (ABIN7230470)

Target: Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Product Details

Binding Specificity: AA 170-250

Purpose: PABP2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PABP2 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human PABP2 protein at AA range: 170-250

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details

Target: Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2)

Alternative Name: PABP2

Background: Rabbit Anti-PABP2 Polyclonal Antibody,Polyadenylate-binding protein 2, PABP-2, Poly(A)-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, PABII, Polyadenylate-binding nuclear protein 1,PABPN1 (Poly(A) Binding Protein Nuclear 1) encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. PABPN1 contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.,PABP2

Molecular Weight: observerd band 33kDa

Gene ID: 8106

UniProt: Q86U42