Renin antibody (AA 180-260)

Catalog No. ABIN7223986

This anti-Renin antibody is a Rabbit Polyclonal antibody detecting Renin in WB, ELISA and IHC (p). Suitable for Human.

Quick Overview for Renin antibody (AA 180-260) (ABIN7223986)

Target: Renin (REN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Renin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Renin Antibody

Binding Specificity: AA 180-260

Purpose: Renin Polyclonal Antibody

Specificity: Renin Polyclonal Antibody detects endogenous levels of Renin protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Renin at AA range: 180-260

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Renin

Target: Renin (REN)

Alternative Name: Renin

Background: Rabbit Anti-Renin Polyclonal Antibody,REN, Renin, Angiotensinogenase,Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in REN (renin) have been shown to cause familial hyperproreninemia.,Renin

Molecular Weight: observerd band 40kDa

Gene ID: 5972

UniProt: P00797

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour