ARHGAP11A antibody (AA 440-520)

Catalog No. ABIN7226098

The Rabbit Polyclonal anti-ARHGAP11A antibody is suitable to detect ARHGAP11A in samples from Human and Mouse. It has been validated for ELISA and WB.

Quick Overview for ARHGAP11A antibody (AA 440-520) (ABIN7226098)

Target: ARHGAP11A (rho GTPase Activating Protein 11A (ARHGAP11A))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGAP11A antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-ARHGAP11A Antibody

Binding Specificity: AA 440-520

Purpose: Rabbit Anti-ARHGAP11A Polyclonal Antibody

Specificity: ARHGAP11A Polyclonal Antibody detects endogenous levels of ARHGAP11A protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human ARHGAP11A at AA range: 440-520

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ARHGAP11A

Target: ARHGAP11A (rho GTPase Activating Protein 11A (ARHGAP11A))

Alternative Name: ARHGAP11A

Background: ARHGAP11A, KIAA0013, Rho GTPase-activating protein 11A, Rho-type GTPase-activating protein 11AGTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. ARHGAP11A (Rho GTPase activating protein 11A), also known as KIAA0013 or MGC70740, is a 1,023 amino acid protein that contains one helical Rho-GAP domain and is encoded by a gene located on human chromosome 15. Defects in the gene encoding ARHGAP11A may cause mental retardation. Human chromosome 15 encodes over 700 genes and comprises nearly 3 % of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene.

Molecular Weight: 110kD

Gene ID: 9824

UniProt: Q6P4F7