RNF6 antibody (AA 470-550)

Catalog No. ABIN7231114

This Rabbit Polyclonal antibody specifically detects RNF6 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for RNF6 antibody (AA 470-550) (ABIN7231114)

Target: RNF6 (RING Finger Protein 6 (RNF6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RNF6 Antibody

Binding Specificity: AA 470-550

Purpose: RNF6 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of RNF6 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human RNF6 protein at AA range: 470-550

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for RNF6

Target: RNF6 (RING Finger Protein 6 (RNF6))

Alternative Name: RNF6

Background: Rabbit Anti-RNF6 Polyclonal Antibody,E3 ubiquitin-protein ligase RNF6, RING-type E3 ubiquitin transferase RNF6,RNF6 (Ring Finger Protein 6) is a Protein Coding gene. Diseases associated with RNF6 include Esophageal Cancer and Squamous Cell Carcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Androgen receptor signaling pathway. The protein encoded by RNF6 contains a RING-H2 finger motif. Deletions and mutations in RNF6 were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.,RNF6

Molecular Weight: observerd band 75kDa

Gene ID: 6049

UniProt: Q9Y252

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Cell Size