LKB1 antibody (pThr189)

Catalog No. ABIN7224538

The Rabbit Polyclonal anti-LKB1 antibody has been validated for WB and ELISA. It is suitable to detect LKB1 in samples from Human and Mouse.

Quick Overview for LKB1 antibody (pThr189) (ABIN7224538)

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LKB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-LKB1 Antibody

Binding Specificity: pThr189

Purpose: LKB1 (phospho Thr189) Polyclonal Antibody

Specificity: Phospho-LKB1 (T189) Polyclonal Antibody detects endogenous levels of LKB1 protein only when phosphorylated at T189.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human LKB1 Phospho-Thr189

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for LKB1

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Alternative Name: LKB1

Background: Rabbit Anti-LKB1 (phospho Thr189) Polyclonal Antibody,STK11, LKB1, PJS, Serine/threonine-protein kinase STK11, Liver kinase B1, LKB1, hLKB1, Renal carcinoma antigen NY-REN-19,STK11 (serine/threonine kinase 11), which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in STK11 have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of STK11 have been observed but have not been thoroughly characterized.,serine threonine-protein kinase STK11

Molecular Weight: observerd band 65kDa

Gene ID: 6794

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect