SIGLEC-5,SIGLEC-14 (Internal Region) antibody

Catalog No. ABIN7218076

This Rabbit Polyclonal antibody specifically detects not_set in ELISA, IHC (p) and WB. It exhibits reactivity toward Human.

Quick Overview for SIGLEC-5,SIGLEC-14 (Internal Region) antibody (ABIN7218076)

Target: SIGLEC-5,SIGLEC-14

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Product Details

Binding Specificity: Internal Region

Purpose: Siglec-5/14 Polyclonal Antibody

Specificity: Siglec-5/14 Polyclonal Antibody detects endogenous levels of Siglec-5/14 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Siglec-5/14

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details

Target: SIGLEC-5,SIGLEC-14

Alternative Name: Siglec-5/14

Background: Rabbit Anti-Siglec-5/14 Polyclonal Antibody,SIGLEC5, CD33L2, OBBP2, Sialic acid-binding Ig-like lectin 5, Siglec-5, CD33 antigen-like 2, Obesity-binding protein 2, OB-BP2, OB-binding protein 2, CD170, SIGLEC14, Sialic acid-binding Ig-like lectin 14, Siglec-14,SIGLEC5 encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The sialic acid binding Ig like lectin 5 is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.,Sialic acid-binding Ig-like lectin 5

Molecular Weight: observerd band 60kDa

Gene ID: 8778

UniProt: O15389