TCL1A antibody (AA 30-110)

Catalog No. ABIN7231744

The Rabbit Polyclonal anti-TCL1A antibody (ABIN7231744) specifically detects TCL1A in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for TCL1A antibody (AA 30-110) (ABIN7231744)

Target: TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCL1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TCL1A Antibody

Binding Specificity: AA 30-110

Purpose: Tcl1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of Tcl1

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human Tcl1 protein at AA range: 30-110

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for TCL1A

Target: TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))

Alternative Name: Tcl1

Background: Rabbit Anti-Tcl1 Polyclonal Antibody,T-cell leukemia/lymphoma protein 1A, Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1,Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al. 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) TCL1A (T-Cell Leukemia/Lymphoma 1A) is a Protein Coding gene. Diseases associated with TCL1A include Precursor T-Cell Acute Lymphoblastic Leukemia and T-Cell Leukemia. Among its related pathways are PI3K-Akt signaling pathway and PI3K / Akt Signaling. An important paralog of TCL1A is MTCP1.,Tcl1

Molecular Weight: observerd band 13kDa

Gene ID: 8115

UniProt: P56279

Pathways: Stem Cell Maintenance