Uromodulin antibody (Internal Region)

Catalog No. ABIN7224866

This anti-Uromodulin antibody is a Rabbit Polyclonal antibody detecting Uromodulin in WB and ELISA. Suitable for Human.

Quick Overview for Uromodulin antibody (Internal Region) (ABIN7224866)

Target: Uromodulin (UMOD)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Uromodulin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Uromodulin Antibody

Binding Specificity: Internal Region

Purpose: THP Polyclonal Antibody

Specificity: THP Polyclonal Antibody detects endogenous levels of THP protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human THP

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Uromodulin

Target: Uromodulin (UMOD)

Alternative Name: THP

Background: Rabbit Anti-THP Polyclonal Antibody,UMOD, Uromodulin, Tamm-Horsfall urinary glycoprotein, THP,The protein encoded by UMOD (uromodulin) is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in UMOD are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of UMOD results in multiple transcript variants.,Uromodulin

Molecular Weight: observerd band 70kDa

Gene ID: 7369

UniProt: P07911