Becn2 antibody
Reactivity: Human
WB, IF/ICC
Host: Rabbit
Polyclonal
unconjugated
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- Target
- Becn2
- Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (fixed cells) (IF/ICC)
- Purpose
- Anti-Beclin2 Rabbit Polyclonal Antibody
- Specificity
- This antibody recognizes human and rat Beclin 2.
- Cross-Reactivity
- Human, Rat
- Immunogen
- Synthetic peptide corresponding to mid-protein amino acids of human Beclin 2.
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anti-Becn2 (N-Term) antibody
Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
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Immunoblotting: use at 1-2 μg/mL. A band of ~50 kDa is detected.Detection of Beclin 2 in 20 μg rat liver lysate.
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications. - Restrictions
- For Research Use only
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- Format
- Liquid
- Reconstitution
- Dilute in PBS or medium that is identical to that used in the assay system.
- Concentration
- 1.0 mg/mL
- Buffer
- PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- This antibody is stable for at least one (1) year at -20°C.
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- Target
- Becn2
- Synonyms
- Beclin-2 antibody, Gm104 antibody, beclin 2 antibody, Becn2 antibody
- Background
- Beclin-2,Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1. {PubMed:23954414}.,Autophagy is a catabolic process that results in the degradation of bulk cytoplasmic contents within autophagosomes and lysosomes. Beclin 2 is an Atg6/Beclin family member that functions in two distinct lysosomal degradation pathways, autophagy and the downregulation of certain seven- transmembrane-spanning GPCRs. Its role in GPCR lysosomal degradation does not involve Beclin 1 or other Beclin 1/2-interacting proteins such as ATG14 and VPS34 that function in autophagy. Its role in lysosomal degradation also appears to differ from other autophagy- independent functions previously described for yeast Atg6/Vps30 or mammalian Beclin 1, such as vacuolar protein sorting and EGFR degradation.,Cytoplasm,Beclin-1 autophagy-related pseudogene 1, Beclin-1-like protein 1
- UniProt
- A8MW95
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