CHGB antibody (C-Term)

Catalog No. ABIN7232896

This Rabbit Polyclonal antibody specifically detects CHGB in WB. It exhibits reactivity toward Rat.

Quick Overview for CHGB antibody (C-Term) (ABIN7232896)

Target: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHGB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CHGB Antibody

Binding Specificity: AA 641-655, C-Term

Purpose: Anti-Chromogranin B Rabbit Polyclonal Antibody

Specificity: This antibody recognizes human, mouse, and rat chromogranin B.

Cross-Reactivity: Human, Mouse, Rat

Immunogen: Synthetic peptide derived from the C-terminus (aa 641-655) of CgB (accession no. NP_001810. This sequence is identical in human, mouse, and rat CgB.

Application Details

Application Notes: Immunoblotting: use at 0.1-1.0 μg/mL
These are recommended concentrations.
Enduser should determine optimal concentrations for their applications.Although the predicted mw of CgB is ~76 kDa, the highly acidic nature of CgB causes it to run at a higher mw in SDS-PAGE.
Immunohistochemistry: use at 1-5 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: Lot specific

Buffer: PBS, pH 7.4

Storage: -20 °C,-80 °C

Storage Comment: This antibody is stable for at least one (1) year at -20°C to -70°C. Avoid multiple freeze-thaw cycles.

Target Details for CHGB

Target: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Alternative Name: CHGB

Background: Secretogranin-1,Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.,Chromogranin B (CgB, secretogranin I) is a secretory granule matrix protein expressed in a wide variety of endocrine cells and neurons where it may have both extracellular and intracellular functions. Extracellular roles for CgB are dependent on its proteolytic processing within secretory granules to form smaller peptides that may have a role in the neuroendocrine/sympathoadrenal stress response to systemic infection, and CgB fragments may also have an autocrine inhibitory role in the release of co-stored hormones, such as insulin.,Secreted. Note=Neuroendocrine and endocrine secretory granules.,Chromogranin-B, CgB, Secretogranin I, SgI [Cleaved into: PE-11, GAWK peptide, CCB peptide]

UniProt: P05060