FPR1 antibody

Catalog No. ABIN7232897

The Mouse Monoclonal anti-FPR1 antibody has been validated for WB and IF. It is suitable to detect FPR1 in samples from Human.

Quick Overview for FPR1 antibody (ABIN7232897)

Target: FPR1 (Formyl Peptide Receptor 1 (FPR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FPR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: NFPR1

Product Details anti-FPR1 Antibody

Purpose: Anti-FPR1/2 MAb Mouse Monoclonal Antibody

Specificity: This antibody recognizes human FPR1 at aa 305-GQDFRERLI-313 at the amino- terminal portion of the carboxyl-terminal tail. It also recognizes the same epitope in FPR2.

Cross-Reactivity: Human

Immunogen: His-tagged recombinant FPR1 (human neutrophil N-formyl peptide receptor 1) expressed in and purified from Sf9 cells.

Isotype: IgG1

Application Details

Application Notes: Immunoblotting: use at 1-5 μg/mL.
Immunofluorescence: use at 10 μg/mL.
These are recommended concentrations.
Enduser should determine optimal concentrations for their application.

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: Lot specific

Buffer: PBS, pH 7.4

Storage: -20 °C,-80 °C

Storage Comment: This product is stable for at least one (1)year at -20°C to -70 C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Target Details for FPR1

Target: FPR1 (Formyl Peptide Receptor 1 (FPR1))

Alternative Name: FPR1

Background: FMet-Leu-Phe receptor,High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520, PubMed:15210802). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium sPubMed:10514456, PubMed:15153520, PubMed:2161213, PubMed:2176894, PubMed:25109685, PubMed:10514456, PubMed:1712023, PubMed:2161213, PubMed:2176894}.,Formyl peptide receptors (FPR) are G protein-coupled receptors that are activated by different agonists included N- formylated peptides originating from bacteria and mitochondria. In humans, the FPR family includes the high affinity FPR1, the low affinity FPR2/ALX (previously known as FPRL1 or ALX) and FPR3. Human FPR1 is important for phagocyte chemotaxis, superoxide production, and degranulation, and helps direct phagocytes to sites of infection. Functional FPR1expression has been demonstrated on fibroblasts, bone marrow mesenchymal stem cells, A549 lung cells, HEP-G2 hepatoma cells, and on several types of epithelial cells.,Cell membrane,fMLP receptor, N-formyl peptide receptor, FPR, N-formylpeptide chemoattractant receptor

UniProt: P21462