KCNV1 antibody (Intracellular)

Catalog No. ABIN7237777

The Rabbit Polyclonal anti-KCNV1 antibody (ABIN7237777) specifically detects KCNV1 in WB. The antibody is reactive with Rat samples.

Quick Overview for KCNV1 antibody (Intracellular) (ABIN7237777)

Target: KCNV1 (Potassium Channel, Subfamily V, Member 1 (KCNV1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNV1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KCNV1 Antibody

Binding Specificity: AA 171-184, Intracellular

Purpose: A Rabbit Polyclonal antibody to KV8.1 (KCNV1)

Specificity: Intracellular, N-terminus.

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Mouse - identical, Human - 13 out of 14 amino acid residues identical

Characteristics: Intracellular, N-terminus

Purification: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)KKDTDDQESQHESE, corresponding to amino acid residues 171 - 184 of rat KCNV1

Isotype: IgG

Application Details

Application Notes:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200-1:500

Comment:

Negative Control: (ABIN7236341)

Blocking Peptide: (ABIN7236341)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Storage: 4 °C,-20 °C

Storage Comment:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Details for KCNV1

Target: KCNV1 (Potassium Channel, Subfamily V, Member 1 (KCNV1))

Alternative Name: KCNV1

Background: Potassium Voltage-Gated Channel Subfamily V Member 1,Voltage-gated K+ channels (KV) are large and diverse ion channel family with more than 40 members found in all kingdoms of life. The activity of KV results in the generation and propagation of membrane potential. A wide range of physiological activities are regulated via KV actions among them, cell signaling, proliferation and migration. KV divided into 12 sub-families, KV1- KV12 based on their amino acid sequence homology1. The electrically silent voltage-gated K+ (KVS) is a subfamily of four KV (KV5, KV6, KV8 and KV9) that do not assembles into a functional homotetrameric channel. KVS is known to generate a functional heterotetrameric complex with KV2 subunits at the plasma membrane1,2.KV8.1 is a member of the KVS family that was first cloned in 1996 and share 40 % identity with other KV channels. Based on sequence homology KV8.1 appear to contain six transmembrane segments (S1-S6), and cytoplasmic N and C termini. Heterotetrameric Kv2.1/KV8.1 was found to have activation V1/2 of 10 to 19 mV and inactivation V1/2 of -63 mV. In recent studies Kv8.1 is found to be involved in epilepsy 2.

Alternative names: Potassium Voltage-Gated Channel Subfamily V Member 1

Gene ID: 60326

NCBI Accession: NM_014379

UniProt: P97557