ABAT antibody

Catalog No. ABIN7265336

The Rabbit Monoclonal anti-ABAT antibody is suitable to detect ABAT in samples from Human. It has been validated for WB and IHC.

Quick Overview for ABAT antibody (ABIN7265336)

Target: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ABAT antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ABAT Antibody

Purpose: GABA transaminase (ABAT) Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human GABA transaminase (GABA transaminase (ABAT))

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ABAT

Target: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Alternative Name: ABAT

Background: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95 % similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008],GABA-AT, GABAT, NPD009,Amino acid metabolism,Cancer,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial metabolism_Mitochondrial markers,Neurodegenerative Diseases Markers,Neuroscience,Other Neurological disorders,Signal Transduction,ABAT

Molecular Weight: 50kDa

Gene ID: 18

UniProt: P80404

Pathways: Monocarboxylic Acid Catabolic Process