ACVR2B antibody (AA 50-150)

Catalog No. ABIN7265414

The Rabbit Polyclonal anti-ACVR2B antibody has been validated for WB and IF. It is suitable to detect ACVR2B in samples from Human.

Quick Overview for ACVR2B antibody (AA 50-150) (ABIN7265414)

Target: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVR2B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-ACVR2B Antibody

Binding Specificity: AA 50-150

Purpose: ACVR2B Rabbit pAb

Sequence: EGEQDKRLHC YASWRNSSGT IELVKKGCWL DDFNCYDRQE CVATEENPQV YFCCCEGNFC NERFTHLPEA GGPEVTYEPP PTAPTLLTVL AYSLLPIGGL S

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ACVR2B (NP_001097.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ACVR2B

Target: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Alternative Name: ACVR2B

Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.,ACVR2B,ACTRIIB,ActR-IIB,HTX4,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,Stem Cells,ACVR2B

Molecular Weight: 57kDa

Gene ID: 93

UniProt: Q13705

Pathways: Hormone Transport, Cancer Immune Checkpoints