APC antibody

Catalog No. ABIN7265452

This Rabbit Monoclonal antibody specifically detects APC in WB and IP. It exhibits reactivity toward Human.

Quick Overview for APC antibody (ABIN7265452)

Target: APC (Adenomatous Polyposis Coli (APC))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This APC antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-APC Antibody

Purpose: APC Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human APC

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IP,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for APC

Target: APC (Adenomatous Polyposis Coli (APC))

Alternative Name: APC

Background: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008],APC,BTPS2,DP2,DP2.5,DP3,GS,PPP1R46,Apoptosis,Cancer,Cardiovascular,Cell Adhesion,Cell Biology & Developmental Biology,Cell Cycle,Cell Cycle_Centrosome,Cell Type Marker,Cell Type Marker_Oligodendrocyte marker,Cytoskeleton_Microtubules,Epigenetics & Nuclear Signaling,ESC Pluripotency and Differentiation,Heart,Heart_Cardiogenesis,Neuroscience,Signal Transduction,Stem Cells,Transcription Factors,Tumor suppressors,Wnt/β-Catenin Signaling Pathway,APC

Molecular Weight: 160kDa

Gene ID: 324

UniProt: P25054

Pathways: WNT Signaling, Stem Cell Maintenance, Cell-Cell Junction Organization