FBXW2 antibody (AA 1-250)

Catalog No. ABIN7267081

This Rabbit Polyclonal antibody specifically detects FBXW2 in WB. It exhibits reactivity toward Human.

Quick Overview for FBXW2 antibody (AA 1-250) (ABIN7267081)

Target: FBXW2 (F-Box and WD Repeat Domain Containing 2 (FBXW2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FBXW2 Antibody

Binding Specificity: AA 1-250

Purpose: FBXW2 Rabbit pAb

Sequence: MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET LLKRDFLKLL PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT ACKNLGWQID DSVQDALHWK KVYLKAILRM KQLEDHEAFE TSSLIGHSAR VYALYYKDGL LCTGSDDLSA KLWDVSTGQC VYGIQTHTCA AVKFDEQKLV TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYNDELDI LVSGSADFTV

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human FBXW2 (NP_036296.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FBXW2

Target: FBXW2 (F-Box and WD Repeat Domain Containing 2 (FBXW2))

Alternative Name: FBXW2

Background: F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.,FBXW2,FBW2,Fwd2,Md6,Cell Biology & Developmental Biology,Ubiquitin,FBXW2

Molecular Weight: 44kDa/51kDa

Gene ID: 26190

UniProt: Q9UKT8