HSPA2 antibody

Catalog No. ABIN7267579

This Rabbit Monoclonal antibody specifically detects HSPA2 in WB and IF. It exhibits reactivity toward Human.

Quick Overview for HSPA2 antibody (ABIN7267579)

Target: HSPA2 (Heat Shock 70kDa Protein 2 (HSPA2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HSPA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-HSPA2 Antibody

Purpose: HSPA2 Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human HSPA2

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HSPA2

Target: HSPA2 (Heat Shock 70kDa Protein 2 (HSPA2))

Alternative Name: HSPA2

Background: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity.,HSP70-2, HSP70-3,Cancer,Endocrine & Metabolism,Mitochondrial metabolism,Signal Transduction,Tumor biomarkers,HSPA2

Molecular Weight: 70kDa

Gene ID: 3306

UniProt: P54652